Implementation of pattern-mixture models in randomized clinical trials
نویسندگان
چکیده
منابع مشابه
Missing data in clinical trials: from clinical assumptions to statistical analysis using pattern mixture models.
The need to use rigorous, transparent, clearly interpretable, and scientifically justified methodology for preventing and dealing with missing data in clinical trials has been a focus of much attention from regulators, practitioners, and academicians over the past years. New guidelines and recommendations emphasize the importance of minimizing the amount of missing data and carefully selecting ...
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Methods for dealing with missing data in clinical trials have been receiving increasing attention from the regulators, practitioners and academicians in the pharmaceutical industry over the past years. New guidelines and recommendations place a great emphasis not only on the importance of carefully selecting primary analysis methods based on clearly formulated assumptions regarding the missingn...
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Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...
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ژورنال
عنوان ژورنال: Pharmaceutical Statistics
سال: 2016
ISSN: 1539-1604
DOI: 10.1002/pst.1780